Перепрофилирование лекарственных препаратов для лечения психических расстройств
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Аннотация
Многофакторность этиологии психических расстройств и несовершенство диагностических подходов затрудняют разработку более эффективных лекарственных препаратов. Перепрофилирование ранее одобренных терапевтических агентов служит одним из перспективных подходов в поиске новых средств лечения психических расстройств. Это связано с тем, что, во-первых, данный подход является менее ресурсо- и экономически затратным по сравнению с иными направлениями разработки лекарственных средств. Во-вторых, методы поиска препаратов — кандидатов для перепрофилирования очень разнообразны и охватывают самые разные аспекты патогенеза психических расстройств. Исследовательская работа в области перепрофилирования лекарственных средств может расширить понимание механизмов развития психической патологии и в то же время способствовать оптимизации терапевтических и профилактических подходов в курации пациентов с данной группой расстройств. В настоящем обзоре кратко охарактеризовано разнообразие подходов к перепрофилированию препаратов c акцентом на методы in silico, а также приведены примеры успешных случаев перепрофилирования препаратов в психиатрии.
Ключевые слова
перепрофилирование лекарств в психиатрии, основные подходы к перепрофилированию, лекарственные мишени, генетические исследования
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