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No. 1 (2020)

PSYCHOPHARMACOTHERAPY

INFLUENCE OF SINGLE NUCLEOTIDE VARIANTOF GENE LEP (RS3828942) ON ANTIPSYCHOTIC-INDUCED ABNORMAL GLUCOSE METABOLISMIN PATIENTS WITH SCHIZOPHRENIA

https://doi.org/10.21265/PSYPH.2020.37.30.002

Published 2020-06-30

  • V.S. Dobrodeeva
    • ,
  • M.Yu. Tolmachev
    • ,
  • N.A. Shnayder
    • ,
  • N.G. Neznanov
    • ,
  • R.F. Nasyrova

V.S. Dobrodeeva
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology

M.Yu. Tolmachev
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology

N.A. Shnayder
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology

N.G. Neznanov
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology

R.F. Nasyrova
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, P.P. Kashchenko Psychiatric Hospital No 1, Kazan Federal University

Abstract

Purpose: To study the influence of the polymorphic variant of the LEP gene Lys656Asn (rs3828942) on antipsychotic<induced changes in glucose concentration in patients residing in the
European part of Russian Federation.
Materials and methods: A prospective study included 117 adult patients based on the presence of F2 disorders according to ICD<10 and the absence of serious somatic disorders residing
in the European part of Russian Federation. Patients took antipsychotics in monotherapy.
Results: A allele of Lys656Asn polymorphism (rs3828942) of the LEP gene is associated with glucose concentration more than 6.1 mmol/L during antipsychotic therapy
Conclusions: Genetic polymorphisms of the leptin system (LEP Lys656Asn) could be a predictor of pre<diabetic state development during antipsychotic therapy.

Keywords

ANTIPSYCHOTIC MONOTHERAPY, GLUCOSE MOLECULAR GENETICS, LEP LYS656ASN

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