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No. 3 (2020)

PSYCHOPHARMACOTHERAPY

A FRESH APPROACH TO THE PATHOGENESIS OF DEPRESSION: IS THE APPEARANCE OF RAPID-ACTING ANTIDEPRESSANTS POSSIBLE?

https://doi.org/10.21265/PSYPH.2020.79.58.001

Published 2020-09-30

  • S.N. Mosolov
    • ,
  • E.Yu. Fedorova

S.N. Mosolov
Moscow Research Institute of Psychiatry – Branch of the V.P. Serbsky National Medical Research Center of Psychiatry and Narcology of the Ministry of Health of the Russian Federation

E.Yu. Fedorova
Moscow Research Institute of Psychiatry - Branch of the V.P. Serbsky National Medical Research Center of Psychiatry and Narcology of the Ministry of Health of the Russian Federation

Abstract

Major depressive disorder (MDD) is one of the most common and high-cost mental disorders. Currently, the monoamine theory of depression is relevant, but about 20 years ago, the discovery of the antidepressant properties of ketamine, which is an antagonist of NMDA receptors, served as an impetus for revising the views on the pathogenesis of depression and creating the concept of rapid-acting antidepressants. This review summarizes the mechanism of action of ketamine as a rapid-acting antidepressant and considers the role of glutamatergic and serotoninergic systems. The search was carried out on the PubMed and Google Scholar databases for the following keywords: ketamine, NMDA, AMPA, rapid-action antidepressant, glutamatergic system, serotoninergic system.

Keywords

ketamine, Nmda, Ampa, glutamatergic system, serotoninergic system, rapid-action antidepressant

PDF (Русский)

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