Metabolic Consequences of Antipsychotic Therapy: Psychiatrists’ Opinion
Abstract
Relevance. The American Psychiatric Association (APA), in collaboration with other medical societies, developed recommendations for the monitoring of metabolic syndrome in patients taking antipsychotics back in 2004. Despite these simple recommendations and recognition by psychiatrists of the importance of monitoring metabolic disorders, a number of studies indicate non-compliance with these recommendations by physicians prescribing antipsychotics.
The aim — to study the level of awareness, attitudes and compliance of psychiatrists with the basic recommendations for monitoring metabolic disorders in patients taking antipsychotics, as well as the perceived barriers to its implementation.
Material and methods. An anonymous survey of 70 psychiatrists in Kemerovo and Tomsk was conducted using the questionnaire “Primary Care Providers’ Views on Metabolic Monitoring of Outpatients Taking Antipsychotic Medication”, developed for primary care physicians in order to assess their attitudes toward barriers to monitoring metabolic disorders in patients and characterize their beliefs about responsibility for conducting such monitoring.
Results. The majority (97.1%) of physicians were well aware of the metabolic risks associated with antipsychotic drugs. At the same time, 70% of physicians agreed with the statement that individuals with schizophrenia are at higher risk of developing metabolic disorders than the rest of the population. Although many (40.1%) believe that monitoring risk factors for metabolic disorders is the responsibility of primary care physicians, most psychiatrists surveyed still agreed that this task is part of their responsibilities. About half (51.4%) of respondents disagreed with the statement that it is the responsibility of a psychiatrist to prescribe medications to treat elements of metabolic dysfunction. Among all possible obstacles, the greatest impact on monitoring, according to psychiatrists, is the lack of medications in their arsenal for the correction of metabolic disorders — 18.6%.
Conclusion. A survey of psychiatrists regarding the monitoring of metabolic disorders in patients taking antipsychotics indicates a high degree of awareness of the side effects of antipsychotic therapy and a willingness to cooperate in screening. However, the main obstacle on this path, according to psychiatrists, is the lack of drugs in their arsenal to correct metabolic disorders.
Keywords
survey, opinion of psychiatrists, schizophrenia, metabolic syndrome, metabolic disorders, monitoring
References
- Allison S., Bastiampillai T., Looi J.C. et al. The new World Mental Health Report: Believing impossible things // Australas Psychiatry. – 2023. – Vol. 31. – Pp. 182–185. – https://doi.org/10.1177/10398562231154806
- Wu Y., Wang L., Tao M. et al. Changing trends in the global burden of mental disorders from 1990 to 2019 and predicted levels in 25 years // Epidemiol Psychiatr Sci. – 2023. – Vol. 32. – e63. – https://doi.org/10.1017/S2045796023000756
- Медведев В.Э. Применение антипсихотиков в реальной клинической практике в России (по результатам программы EPIDEMICUS) // Неврология, нейропсихиатрия, психосоматика. – 2025. – № 1. – С. 24–33. – https://doi.org/10.14412/2074-2711-2025-1-24-33
- Leucht S., Priller J., Davis J.M. Antipsychotic drugs: A concise review of history, classification, indications, mechanism, efficacy, side effects, dosing, and clinical application // Am J Psychiatry. – 2024. – Vol. 181. – Pp. 865–878. – https://doi.org/10.1176/appi.ajp.20240738
- Garakani A., Freire R.C., Buono F.D. et al. An umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol // PLoS One. – 2022. – Vol. 17. – e0269772. – https://doi.org/10.1371/journal.pone.0269772
- Корнетова Е.Г., Герасимова В.И., Гончарова А.А. и др. Метаболический синдром в госпитальной популяции больных шизофренией в регионе Западной Сибири // Психиатрия. – 2021. – № 4. – С. 52–60. – https://doi.org/10.30629/2618-6667-2021-19-4-52-60
- Петрова Н.Н., Семенова Н.В. Метаболический синдром и антипсихотическая терапия шизофрении // Журнал неврологии и психиатрии имени С.С. Корсакова. – 2024. – № 11. – С. 165–170. – https://doi.org/10.17116/jnevro2024124111165
- Abdel Aziz K., Mohd Ahmed H., Stip E. et al. Metabolic syndrome and its relation to antipsychotic polypharmacy in schizophrenia, schizoaffective and bipolar disorders // Int Clin Psychopharmacol. – 2024. – Vol. 39. – Pp. 257–266. – https://doi.org/10.1097/YIC.0000000000000538
- Корнетова Е.Г., Галкин С.А., Корнетов А.Н. и др. Сравнительное исследование метаболических нарушений у стационарных пациентов с шизофренией и аффективными расстройствами // Социальная и клиническая психиатрия. – 2024. – № 2. – С. 5–12.
- Галкин С.А., Корнетова Е.Г., Меднова И.А. и др. Распространенность и факторы риска синдрома удлинения интервала QT у пациентов с шизофренией на фоне приема антипсихотиков // Современная терапия психических расстройств. – 2024. – № 2. – С. 32–39. – https://doi.org/10.21265/PSYPH.2024.31.31.004
- Peng P., Li J., Chen Y. et al. Associations between antipsychotics and the risk of incident cardiovascular diseases in individuals with schizophrenia: A nested case–control study // BMJ Ment Health. – 2023. – Vol. 26. – e300501. – https://doi.org/10.1136/bmjment-2022-300501
- American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists; North American Association for the Study of Obesity. Consensus development conference on antipsychotic drugs and obesity and diabetes // Diabetes Care. – 2004. – Vol. 27. – Pp. 596–601. – https://doi.org/10.2337/diacare.27.2.596
- Essock S.M., Covell N.H., Leckman–Westin E. et al. Identifying clinically questionable psychotropic prescribing practices for medicaid recipients in New York State // Psychiatr Serv. – 2009. – Vol. 60. – Pp. 1595–602. – https://doi.org/10.1176/ps.2009.60.12.1595
- Morrato E.H., Druss B., Hartung D.M. et al. Metabolic testing rates in 3 state medicaid programs after FDA warnings and ADA/APA recommendations for second-generation antipsychotic drugs // Arch Gen Psychiatry. – 2010. – Vol. 67. – Pp. 17–24. – https://doi.org/10.1001/archgenpsychiatry.2009.179
- Mangurian C., Giwa F., Shumway M. et al. Primary care providers’ views on metabolic monitoring of outpatients taking antipsychotic medication // Psychiatr Serv. – 2013. – Vol. 64. – Pp. 597–599. – https://doi.org/10.1176/appi.ps.002542012
- McLaren J.L., Brunette M.F., McHugo G.J. et al. Monitoring of patients on second-generation antipsychotics: a national survey of child psychiatrists // Psychiatr Serv. – 2017. – Vol. 68. – Art. 961. – https://doi.org/10.1176/appi.ps.201500553
- Клинические рекомендации. Шизофрения. Взрослые / Минздрав РФ. – Москва, 2024. – 217 с.
- Kornetova E.G., Kornetov A.N., Mednova I.A. et al. Changes in body fat and related biochemical parameters associated with atypical antipsychotic drug treatment in schizophrenia patients with or without metabolic syndrome // Front Psychiatry. – 2019. – Vol. 10. – Art. 803. – https://doi.org/10.3389/fpsyt.2019.00803
- Abdulhaq B., Dardas L.A., Sami O. Monitoring for the metabolic side effects of second–generation antipsychotic medications: Psychiatrists’ views and practices // Perspect Psychiatr Care. – 2021. – Vol. 57. – Pp. 1237–1243. – https://doi.org/10.1111/ppc.12679
- Ijaz S., Bolea B., Davies S. et al. Antipsychotic polypharmacy and metabolic syndrome in schizophrenia: A review of systematic reviews // BMC Psychiatry. – 2018. – Vol. 18. – Art. 275. – https://doi.org/10.1186/s12888-018-1848-y
- Горобец Л.Н., Буланов В.С., Литвинов А.В. Эффективность и переносимость коррекционной терапии частичным агонистом дофаминовых рецепторов арипипразолом нейролептической гиперпролактинемии у больных с расстройствами шизофренического спектра // Социальная и клиническая психиатрия. – 2023. – № 2. – С. 42–50.
- Siwek M., Wojtasik–Bakalarz K., Krupa A.J., Chrobak A.A. Brexpiprazole-pharmacologic properties and use in schizophrenia and mood disorders // Brain Sci. – 2023. – Vol. 13. – Art. 397. – https://doi.org/10.3390/brainsci13030397
- Медведев В.Э. Комплексная терапия шизофрении: проблемы и решения // Психиатрия и психофармакотерапия. – 2023. – № 5. – С. 29–42.
- Быков Ю.В., Беккер Р.А. Антипсихотик третьего поколения арипипразол: эффективность и безопасность при расстройствах шизофренического спектра (анализ современных данных) // Психиатрия и психофармакотерапия. – 2023. – № 2. – С. 17–34.
- Allison S., Bastiampillai T., Looi J.C. et al. The new World Mental Health Report: Believing impossible things // Australas Psychiatry. – 2023. – Vol. 31. – Pp. 182–185. – https://doi.org/10.1177/10398562231154806
- Wu Y., Wang L., Tao M. et al. Changing trends in the global burden of mental disorders from 1990 to 2019 and predicted levels in 25 years // Epidemiol Psychiatr Sci. – 2023. – Vol. 32. – e63. – https://doi.org/10.1017/S2045796023000756
- Медведев В.Э. Применение антипсихотиков в реальной клинической практике в России (по результатам программы EPIDEMICUS) // Неврология, нейропсихиатрия, психосоматика. – 2025. – № 1. – С. 24–33. – https://doi.org/10.14412/2074-2711-2025-1-24-33
- Leucht S., Priller J., Davis J.M. Antipsychotic drugs: A concise review of history, classification, indications, mechanism, efficacy, side effects, dosing, and clinical application // Am J Psychiatry. – 2024. – Vol. 181. – Pp. 865–878. – https://doi.org/10.1176/appi.ajp.20240738
- Garakani A., Freire R.C., Buono F.D. et al. An umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol // PLoS One. – 2022. – Vol. 17. – e0269772. – https://doi.org/10.1371/journal.pone.0269772
- Корнетова Е.Г., Герасимова В.И., Гончарова А.А. и др. Метаболический синдром в госпитальной популяции больных шизофренией в регионе Западной Сибири // Психиатрия. – 2021. – № 4. – С. 52–60. – https://doi.org/10.30629/2618-6667-2021-19-4-52-60
- Петрова Н.Н., Семенова Н.В. Метаболический синдром и антипсихотическая терапия шизофрении // Журнал неврологии и психиатрии имени С.С. Корсакова. – 2024. – № 11. – С. 165–170. – https://doi.org/10.17116/jnevro2024124111165
- Abdel Aziz K., Mohd Ahmed H., Stip E. et al. Metabolic syndrome and its relation to antipsychotic polypharmacy in schizophrenia, schizoaffective and bipolar disorders // Int Clin Psychopharmacol. – 2024. – Vol. 39. – Pp. 257–266. – https://doi.org/10.1097/YIC.0000000000000538
- Корнетова Е.Г., Галкин С.А., Корнетов А.Н. и др. Сравнительное исследование метаболических нарушений у стационарных пациентов с шизофренией и аффективными расстройствами // Социальная и клиническая психиатрия. – 2024. – № 2. – С. 5–12.
- Галкин С.А., Корнетова Е.Г., Меднова И.А. и др. Распространенность и факторы риска синдрома удлинения интервала QT у пациентов с шизофренией на фоне приема антипсихотиков // Современная терапия психических расстройств. – 2024. – № 2. – С. 32–39. – https://doi.org/10.21265/PSYPH.2024.31.31.004
- Peng P., Li J., Chen Y. et al. Associations between antipsychotics and the risk of incident cardiovascular diseases in individuals with schizophrenia: A nested case–control study // BMJ Ment Health. – 2023. – Vol. 26. – e300501. – https://doi.org/10.1136/bmjment-2022-300501
- American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists; North American Association for the Study of Obesity. Consensus development conference on antipsychotic drugs and obesity and diabetes // Diabetes Care. – 2004. – Vol. 27. – Pp. 596–601. – https://doi.org/10.2337/diacare.27.2.596
- Essock S.M., Covell N.H., Leckman–Westin E. et al. Identifying clinically questionable psychotropic prescribing practices for medicaid recipients in New York State // Psychiatr Serv. – 2009. – Vol. 60. – Pp. 1595–602. – https://doi.org/10.1176/ps.2009.60.12.1595
- Morrato E.H., Druss B., Hartung D.M. et al. Metabolic testing rates in 3 state medicaid programs after FDA warnings and ADA/APA recommendations for second-generation antipsychotic drugs // Arch Gen Psychiatry. – 2010. – Vol. 67. – Pp. 17–24. – https://doi.org/10.1001/archgenpsychiatry.2009.179
- Mangurian C., Giwa F., Shumway M. et al. Primary care providers’ views on metabolic monitoring of outpatients taking antipsychotic medication // Psychiatr Serv. – 2013. – Vol. 64. – Pp. 597–599. – https://doi.org/10.1176/appi.ps.002542012
- McLaren J.L., Brunette M.F., McHugo G.J. et al. Monitoring of patients on second-generation antipsychotics: a national survey of child psychiatrists // Psychiatr Serv. – 2017. – Vol. 68. – Art. 961. – https://doi.org/10.1176/appi.ps.201500553
- Клинические рекомендации. Шизофрения. Взрослые / Минздрав РФ. – Москва, 2024. – 217 с.
- Kornetova E.G., Kornetov A.N., Mednova I.A. et al. Changes in body fat and related biochemical parameters associated with atypical antipsychotic drug treatment in schizophrenia patients with or without metabolic syndrome // Front Psychiatry. – 2019. – Vol. 10. – Art. 803. – https://doi.org/10.3389/fpsyt.2019.00803
- Abdulhaq B., Dardas L.A., Sami O. Monitoring for the metabolic side effects of second–generation antipsychotic medications: Psychiatrists’ views and practices // Perspect Psychiatr Care. – 2021. – Vol. 57. – Pp. 1237–1243. – https://doi.org/10.1111/ppc.12679
- Ijaz S., Bolea B., Davies S. et al. Antipsychotic polypharmacy and metabolic syndrome in schizophrenia: A review of systematic reviews // BMC Psychiatry. – 2018. – Vol. 18. – Art. 275. – https://doi.org/10.1186/s12888-018-1848-y
- Горобец Л.Н., Буланов В.С., Литвинов А.В. Эффективность и переносимость коррекционной терапии частичным агонистом дофаминовых рецепторов арипипразолом нейролептической гиперпролактинемии у больных с расстройствами шизофренического спектра // Социальная и клиническая психиатрия. – 2023. – № 2. – С. 42–50.
- Siwek M., Wojtasik–Bakalarz K., Krupa A.J., Chrobak A.A. Brexpiprazole-pharmacologic properties and use in schizophrenia and mood disorders // Brain Sci. – 2023. – Vol. 13. – Art. 397. – https://doi.org/10.3390/brainsci13030397
- Медведев В.Э. Комплексная терапия шизофрении: проблемы и решения // Психиатрия и психофармакотерапия. – 2023. – № 5. – С. 29–42.
- Быков Ю.В., Беккер Р.А. Антипсихотик третьего поколения арипипразол: эффективность и безопасность при расстройствах шизофренического спектра (анализ современных данных) // Психиатрия и психофармакотерапия. – 2023. – № 2. – С. 17–34.
