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No. 1 (2025)

CASE REPORTS

The Effect of Electroconvulsive Therapy on the Dynamics of Blood Brain Barrier Permeability Biomarkers and Electroencephalogram Characteristics in Patient with Schizophrenia (Clinical Case Description)

https://doi.org/10.48612/psyph/419u-5b3k-6mur

Published 2025-03-30

  • D.I. Malin
    • ,
  • O.V. Pavlova
    • ,
  • S.P. Bayramova
    • ,
  • O.I. Gurina
    • ,
  • S.N. Mosolov

D.I. Malin
V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology of the Ministry of Heath of the Russian Federation

O.V. Pavlova
V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology of the Ministry of Heath of the Russian Federation

S.P. Bayramova
V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology of the Ministry of Heath of the Russian Federation

O.I. Gurina
V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology of the Ministry of Heath of the Russian Federation

S.N. Mosolov
V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology of the Ministry of Heath of the Russian Federation; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

Abstract

This paper describes the use of electroconvulsive therapy (ECT) in a patient with schizophrenia presenting with verbal pseudohallucinosis syndrome and resistant to antipsychotic therapy. The effect of ECT on the dynamics of blood-brain barrier (BBB) permeability biomarkers and electroencephalogram characteristics was assessed. A total of 12 ECT sessions were performed under anesthesia and muscle relaxants. The treatment resulted in an improvement of the patient’s mental state with a reduction of more than 30 % of symptoms according to the Positive and Negative Syndrome Scale (PANSS). ECT resulted in damage to the BBB with an increase of neuron-specific enolase (NSE) antibody titers. These changes correlated with negative EEG dynamics, manifested by an increase in slow wave activity. The results obtained are of great practical and theoretical importance and require further confirmation in a representative sample of patients.

Keywords

electroconvulsive therapy, treatment-resistant schizophrenia, blood-brain barrier permeability biomarkers, electroencephalography, glial fibrillary acidic protein, neuron-specific enolase

PDF (Русский)

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