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Peer-reviewed scientific and practical journal · since 2006

ISSN 2306-4137
Современная терапия психических расстройств
Current Therapy of Mental Disorders

ORIRGINAL RESEARCH

Association Analysis of Polygenic Risk Scores for Cardiovascular Diseases, Associated Biochemistry Characteristics and Depression: Perspectives on the Use of Somatic Drugs in Comorbid Conditions

Author information
G.V. Rukavishnikov
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
D.E. Bolotova
First St. Petersburg State Medical University named after I.P. Pavlov
E.D. Kasyanov
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
A.S. Rakitko
«Genotek» Ltd.
N.G. Neznanov
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; First St. Petersburg State Medical University named after I.P. Pavlov
A.O. Kibitov
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; First St. Petersburg State Medical University named after I.P. Pavlov
G.E. Mazo
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
Published
March 30, 2025
Pages
2-9
PDF (Русский)

Abstract

The aim of this study was to assess the association between polygenic risk scores (PRS) for a series of cardiovascular diseases (CVDs) and associated biochemistry characteristics with phenotypes of affective disorders.

Material and methods. Data analysis was performed on a sample of 4,520 clients of the Russian private genetic company “Genotek” (women — 50.4 % of the sample; the average age of participants was 36.8 (standard deviation (SD) = 9.8) years). Symptoms of depression and anxiety were assessed using online phenotyping based on DSM-5 criteria and the Hospital Anxiety and Depression Scale (HADS). To search for genetic associations, the main CVDs phenotypes and associated biochemical parameters (lipid spectrum, omega-3 fatty acids) with summary statistics in the UK Biobank were selected.

Results. Polygenic risk score for ischemic stroke was effective against the maximum number of online phenotypes of depression and anxiety — 11 (78.6 %) with a part of phenotypes with depression symptoms of 82 %. Polygenic risk score for omega-3 fatty acid level increased the risk of manifestation of 5 (42.6 %) research phenotypes, 67 % of which reflect symptoms of depression. Polygenic risk score for total cholesterol level increased the risk of manifestation of 2 (14.3 %) phenotypes. At the same time, it is noteworthy that the strongest associations were identified for the phenotypes of atypical depression variants.

Conclusions. The analysis showed а significant genetic associations for both a series of biochemical markers (cholesterol level, omega-3 fatty acids) and certain somatic nosologies (ischemic stroke) with phenotypes of depression and anxiety. The use of a number of somatic drugs, considering their shared pathological “targets” (lipid metabolism, fatty acid metabolism, the renin-angiotensin-aldosterone system, the coagulation system) can become an effective solution for managing comorbid conditions.

Keywords

  • depression
  • cardiovascular diseases
  • lipid metabolism
  • polyunsaturated fatty acids
  • renin-angiotensin-aldosterone system
  • polygenic risk scores

How to Cite

Rukavishnikov, . G., Bolotova, D., Kasyanov, . E., Rakitko, A., Neznanov, N., Kibitov, A., & Mazo, G. (2025). Association Analysis of Polygenic Risk Scores for Cardiovascular Diseases, Associated Biochemistry Characteristics and Depression: Perspectives on the Use of Somatic Drugs in Comorbid Conditions. [Sovremennaa Terapia Psihiceskih Rasstrojstv] = Current Therapy of Mental Disorders, (1), 2–9. https://doi.org/10.48612/psyph/9urd-73g5-z44z
Endnote/Zotero/Mendeley (RIS) BibTeX

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