INFLUENCE OF LURAZIDONE ON COGNITIVE FUNCTIONING OF SCHIZOPHRENIA PATIENTS: A SYSTEMATIC REVIEW OF THE EVIDENCES

Abstract

The article provides a brief overview of the state-of-art view on the place of cognitive impairments in the structure of the schizophrenic process and the therapeutic potential of atypical antipsychotics in its correction. The most important results of a number of clinical studies assessed the effect of lurasidone on the cognitive functioning in schizophrenic patients are highlighted, and the data of two randomized clinical trials were summarized in systematic manner. The analysis of all available data convincingly demonstrated the ability of lurazidone to significantly improve directly not only patient perfomance in cognitive tests, but also their personal and social functioning both in comparison with placebo and with active comparators (ziprasidone and quetiapine XR).