Skip to main navigation menu Skip to main content Skip to site footer

No. 2 (2024)

PRACTICE

Use of Valproic Acid in Complex Therapy of Post-Covid Mental Disorders (Clinical Case)

https://doi.org/10.21265/PSYPH.2024.31.31.007

Published 2024-06-30

  • N.I. Raspopova

N.I. Raspopova
Kazakh-Russian Medical University

Abstract

The results of recent international studies indicate that individuals who have had COVID-19, in the clinic of post-covid syndrome, often experience mental disorders in the form of increased irritability, depressed mood, anxiety, memory impairment and reduced intellectual productivity. The researchers pay particular attention to the most common anxiety-depressive disorders, which significantly reduce the quality of life and in some cases can increase the risk of suicide, which determines the relevance and social importance of developing measures to improve the quality of psychiatric care for these individuals. This paper presents a clinical case demonstrating the clinic and dynamics of the development of a protracted course of post-covid anxiety-depressive disorder and the selection of effective complex psycho-pharmacotherapy using the valproic acid. The advisability of including drugs from the group of mood stabilizers in the complex psychopharmacotherapy of protracted forms of post-covid mental disorders is discussed.

Keywords

post-covid mental disorders, anxiety, depression, valproic acid

PDF (Русский)

References

  1. Schwartz B.J. New APA survey on public anxiety over COVID-19. High Anxiety in America Over COVID-19 // Medscape. – 2020, Mar 28.
  2. Brooks S.K., Webster R.K., Smith L.E. et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence // Lancet. – 2020. – Vol. 395 (10227). – Pp. 912–920. – https://doi.org/10.1016/S0140-6736(20)30460-8
  3. Sher L. The impact of the COVID-19 pandemic on suicide rates // QJM: An International Journal of Medicine. – 2020. – Vol. 113, no. 10. – Pp. 707–712. – https://doi.org/10.1093/qjmed/hcaa202
  4. Krendl A.C., Perry B.L. The impact of sheltering in place during the COVID-19 pandemic on older adults’ social and mental well-being // The Journals of Gerontology: Series B. – 2020. – Vol. 76 (2). – Pp. e53–e58. – https://doi.org/10.1093/geronb/gbaa110
  5. Мосолов С.Н. Проблемы психического здоровья в условиях пандемии COVID-19. // Журнал неврологии и психиатрии имени С.С. Корсакова. – 2020. – T. 120 (5). – C. 156– 164. – https://doi.org/10.17116/jnevro2020120051156.
  6. Сорокин М.Ю., Касьянов Е.Д., Рукавишников Г.В., Макаревич О.В., Незнанов Н.Г., Лутова .Б., Мазо Г.Э. Психологические реакции населения как фактор адаптации к пандемии COVID-19 // Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева. – 2020. – № 2. – С. 87–94. – https://doi.org/10.31363/2313-7053-2020-2-87-94
  7. Мосолов С.Н. Длительные психические нарушения после перенесенной острой коронавирусной инфекции SARSCoV-2 // Современная терапия психических расстройств. – 2021. – № 3. – С. 2–23. – https://doi.org/10.21265/PSYPH.2021.31.25.001
  8. Nalbandian A., Sehgal K., Gupta A. et al. Post-acute COVID-19 syndrome // Nat Med. – 2021. – Vol. 27. – Pp. 601–615. – https://doi.org/10.1038/s41591-021-01283-z
  9. Editorial. Long COVID: Let patients help define long-lasting COVID symptoms // Nature. – 2020. – Vol. 586. – Art. 170. – https://doi.org/10.1038/d41586-020-02796-2
  10. Nabavi N. Long COVID: How to define it and how to manage it // BMJ. – 2020. – Vol. 370. – m3489. – https://doi.org/10.1136/bmj.m348913
  11. Хасанова Д.Р., Житкова Ю.В., Васкаева Г.Р. Постковидный синдром: обзор знаний о патогенезе, нейропсихиатрических проявлениях и перспективах лечения // Неврология, нейропсихиатрия, психосоматика. – 2021. – T. 13 (3). – С. 93–98. – https://doi.org/10.14412/2074-2711-2021-3-93-98
  12. World Health Organization. Available at: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID19_condition-Clinical_case_definition-2021.1 (accessed June 10, 2021).
  13. London R.T. Is COVIDE19 leading to a mental illness pandemic? Presented by ID Practitioner in MDedge Infectious disease. – Available at: https://www.mdedge.com/infectious-disease/article/219612/coronavirusupdates/covidE19leading mental illness pandemic? (accessed April 4, 2020).
  14. Wang S., Quan L., Chavarro J.E. et al. Associations of Depression, Anxiety, Worry, Perceived Stress, and Loneliness Prior to Infection with Risk of Post-COVID-19 Conditions // JAMA Psychiatry. – 2022. – Vol. 79 (11). – Pp. 1081–1091. – https://doi.org/10.1001/jamapsychiatry.2022.2640
  15. Rogers J. P., Chesney E., Oliver D., et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic // The Lancet Psychiatry. – 2020. – Vol. 7 (7). – Pp. 611–627. – https://doi.org/10.1016/S2215-0366(20)30203-0
  16. Xie Y., Xu E., Al-Aly Z. Risks of mental health outcomes in people with covid-19: cohort study // BMJ. – 2022. – Vol. 376. – e068993. – https://doi.org/10.1136/bmj-2021-068993
  17. Woodward S. F., Bari S., Vike N. et al. Anxiety, Post-COVID-19 Syndrome-Related Depression, and Suicidal Thoughts and Behaviors in COVID-19 Survivors: Cross-sectional Study // JMIR Form Res. – 2022. – Vol. 6 (10). – e36656. – https://doi.org/10.2196/36656
  18. Kyzar E. J., Purpura L.J., Shah J., Cantos A., Nordvig A.S., Yin M.T. Anxiety, depression, insomnia, and trauma-related symptoms following COVID-19 infection at long-term follow-up // Brain Behav Immun Health. – 2021. – Vol. 16. – Art. 100315. – https://doi.org/10.1016/j.bbih.2021.100315
  19. Taquet M., Geddes J.R., Husain M., Luciano S., Harrison P.J. 6-month neurological and psychiatric outcomes in 236379 survivors of COVID-19: A retrospective cohort study using electronic health records // Lancet Psychiatry. – 2021. – Vol. 8 (5). – Pp. 416–427. – https://doi.org/10.1016/S2215-0366(21)00084-5
  20. Brooks S.K., Webster R.K., Smith L.E. et al. The psychological impact of quarantine and how to reduce it: Rapid review of the evidence // Lancet. – 2020. – Vol. 395 (10227). – Pp. 912–920. – https://doi.org/10.1016/S0140-6736(20)30460-8
  21. Lai J., Ma S., Wang Y., et al. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019 // JAMA Netw Open. – 2020. – Vol. 3 (3) – e203976. – https://doi.org/10.1001/jamanetworkopen.2020.3976
  22. Медведев В.Э., Доготарь О.А. COVID-19 и психическое здоровье: вызовы и первые выводы // Неврология, нейропсихиатрия, психосоматика. – 2020. – № 12 (6). – С. 4–10. – https://doi.org/10.1001/10.14412/2074-2711-2020-6-4-10
  23. Yang Y., Li W., Zhang Q. et al. Mental health services for older adults in China during the COVID-19 outbreak // Lancet Psychiatry. – 2020. – Vol. 7 (4). – e19. – https://doi.org/10.1001/10.1016/S2215-0366(20)30079-1
  24. Angst. J., Vollrath M., Merikangas K. R., Ernst С. Comporbidity of anxiety and depression in the Zurich Cohort Study of young adults // Comorbidity of Mood and Anxiety Disorders / Maser J. D., Cloninger C.R. – Washington, DC: American Psychiatric Press, 1991. – Pp. 123–153.
  25. Ешимбетова С.З., Распопова Н.И., Дуйсенова А.К., Курбан К.М. Байкадамова З. Тревожно-депрессивные расстройства у пациентов с COVID-19 // Вестник КазНМУ. – 2021. – № 4. – С. 176–182.
  26. Распопова Н.И., Ешимбетова С.З., Джамантаева М.Ш., Сулейменова А.А., Аймакова И.М., Куламкадырова Н.С. Психические нарушения у лиц, перенесших COVID-19, и методы их терапии // Вестник КазНМУ. – 2021. – № 4. – С. 228–234.
  27. Fernandez-de-las-Peñas C., Palacios-Ceña D., Gomez-Mayordomo V. et al. Long-term post-COVID symptoms and associated risk factors in previously hospitalized patients: A multicenter study // J Infect. – 2021. – Vol. 83 (2). – Pp. 237–279. – https://doi.org/10.1016/j.jinf.2021.04.036
  28. Canu E. New Data on COVID-19’s cognitive fallout // Medscape Medical News, EAN 2021, Editor’s note. – Available at: https://www.medscape.com/viewarticle/953478 (accessed August 11, 2021).
  29. Sher L. Are COVID-19 survivors at increased risk for suicide? // Acta Neuropsychiatr. – 2020. – Vol. 32. – Art. 270. – https://doi.org/10.1017/neu.2020.21
  30. Greenhalgh T., Knight M., Court C.A. et al. Management of post-acute SOVID-19 in primary care // BMJ. – 2020. – Vol. 11. – Art. 370. – m3026. – https://doi.org/10.1136/bmj.m3026
  31. National Institute for Health and Care Excellence, 2020. COVID-19 rapid guideline: Managing the long-term effects of COVID-19. NICE guideline [NG188]. – Available at: www.nice.org.uk/guidance/ng188 (accessed June 12, 2021).
  32. Demeco A., Marotta N., Barletta M. et al. Rehabilitation of patients post-COVID-19 infection: A literature review // J Intern Med Res. – 2020. – Vol. 48 (8). – Art. 300060520948382. – https://doi.org/10.1177/0300060520948382
  33. Vink M., Vink-Niese A. Could cognitive behavioural therapy be an effective treatment for long COVID and post COVID-19 fatigue syndrome? Lessons from the qure study for Q-fever fatigue syndrome // Healthcare. – 2020. – Vol. 8 (4). – Art. 552. – https://doi.org/10.3390/healthcare8040552
  34. Vinkers C.H., van Amelsvoort T., Bisson J.I. et al. Stress resilience during the coronavirus pandemic // Eur Neuropsychopharmacol. – 2020. – Vol. 35. – Pp. 12–16. – https://doi.org/10.1016/j.euroneuro.2020.05.003
  35. Freedman S.A. Psychological interventions to prevent PTSD // Psychiatr Ann. – 2019. – Vol. 49. – Pp. 314–319. – https://doi.org/10.3928/00485713-20190528-01
  36. Khawam E., Khouli H., Pozuelo L. Treating acute anxiety in patients with COVID-19 // Cleve Clin J Med. – 2020, May 14. – https://doi.org/10.3929/ccjm.87a.ccc016
  37. Мосолов С.Н. Актуальные задачи психиатрической службы в связи с пандемией COVID-19 // Современная терапия психических расстройств. – 2020. – № 2. – С. 26– 32. – https://doi.org/10.21265/PSYPH.2020.53.59536
  38. Мосолов С.Н. Сравнительная эффективность профилактического применения карбоната лития, карбамазепина, вальпроата натрия при аффективных и шизоаффективных психозах // Журнал невропатологии и психиатрии имени С.С. Корсакова. – 1991. – № 4. – C. 78–83.
  39. Мосолов С.Н., Костюкова Е.Г., Кузавкова М.В. Биполярное аффективное расстройство. Диагностика и терапия. – М.: МЕДпресс-информ, 2008. – 383 с.
  40. Sher L. Are COVID-19 survivors at increased risk for suicide? // Acta Neuropsychiatr. – 2020. – Vol. 32. – Art. 270. – https://doi.org/10.1017/neu.2020.21
  41. Varga Z., Flammer A.J., Steiger P. et al. Endothelial cell infection and endotheliitis in COVID-19 // Lancet. – 2020. – Vol. 395. – Pp. 1417–1418. – https://doi.org/10.1016/S0140-6736(20)30937-5
  42. Deng J., Zhou F., Hou W. et al. The prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients: a meta-analysis // Ann N Y Acad Sci. – 2021. – Vol. 1486 (1). – Pp. 90–111. – https://doi.org/10.1111/nyas.14506
  43. Taquet M., Luciano S., Geddes J.R., Harrison P.J. Bidirectional associations between COVID-19 and psychiatric disorder: a study of 62,354 COVID-19 cases // Lancet Psychiatry. – 2021. – Vol. 8 (2). – Pp. 130–140. – https://doi.org/10.1016/S2215-0366(20)30462-4
  44. Mahmoudi H., Saffari M., Movahedi M. et al. A mediating role for mental health in associations between COVID-19-related self-stigma, PTSD, quality of life, and insomnia among patients recovered from COVID-19 // Brain Behav. – 2021. – Vol. 11. – Pp. 1–8. – https://doi.org/10.1002/brb3.2138
  45. Вовин Р.Я., Аксенова И.О. Затяжные депрессивные состояния. – Л.: Медицина, 1982. – 191 с.
  46. Министерство здравоохранения Российской Федерации. Биполярное аффективное расстройство: клинические рекомендации. – 2021. – URL: https://cr.minzdrav.gov.ru/schema/675_1 (дата обращения 12.09.2023).
  47. Мосолов С.Н., Ушкалова А.В., Костюкова Е.Г., Шафаренко А.А., Алфимов П.В., Костюкова А.Б. Диагностика биполярного аффективного расстройства II типа среди пациентов с текущим диагнозом рекуррентного депрессивного расстройства // Современная терапия психических расстройств. – 2014. – № 2. – С. 2–14.

Downloads

Download data is not yet available.