ANALYSIS OF THE FLUOXETINE AND DULOXETINE EFFECTS ON NORMAL INTESTINAL MICROBIOTA

Abstract

Background. Studying the effect of antidepressants on the gut microbiota will allow us to determine its role in the antidepressant therapy risks of tolerance and side effects, as well as to assess the feasibility of using microbiota-modeling tactics to optimize the treatment of patients with depression. The aim of the study - was to evaluate the antibacterial activity of fluoxetine and duloxetine against representatives of normal human intestinal microbiota. Material and methods. A culture medium containing antidepressant preparations at a concentration of 200, 500, and 1000 μg / ml was added to the suspension of microorganisms. The growth of microorganisms was assessed using a turbodimetric method on a photometer (Multiscan FC). For a quantitative assessment of the action of drugs, the specific growth rates (μ, h-1) of microorganisms are used. Results. Antimicrobial activity against representatives of normal microbiota was revealed in both studied antidepressants. At the same time, duloxetine showed great antibacterial activity against representatives of normal intestinal microbiota. The data obtained indicate the dependence of the effect on the intestinal microbiota on the studied drug and the dose used in the experiment. Conclusions. There is reason to believe that antidepressants can influence the composition of the gut microbiota, which is likely to influence the therapeutic effect. Further studies of the antimicrobial activity of antidepressants against the gut microbiota may become one of the new directions in the optimization of therapy for patients with depression.