Cognitive Impairment in Patients With Schizophrenia

Abstract

Cognitive impairment is the key group of schizophrenia symptoms that occur early in the course of disorder and considered as the major predictor of functional outcome. In this paper we
review contemporary data on the cognitive trajectories in schizophrenia in conjunction with their neurobilological basis. Cognitive impairments may have heterogeneous nature that may be
linked to different phases of the disorder. Neurobiological basics of cognitive deterioration may underly formation of positive and negative symptoms of schizophrenia. An analysis of possible
therapeutic modalities to face cognitive impairment in schizophrenia and their potential was held.