Диагностика и терапия биполярного расстройства
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Аннотация
Выполнен обзор литературы в базах данных PubMed и Google. Критериями включения являлись рандомизированные клинические исследования, метаанализы и систематические обзоры, релевантные полнотекстовые статьи о биполярном аффективном расстройстве. Критериями исключения были статьи низкого качества. Терминология статьи соответствует используемой во включенных в обзор публикациях. В обзоре раскрыта актуальность проблемы биполярного расстройства, в том числе вопросы коморбидности, диагностики и суицидального риска. Обсуждены факторы риска развития заболевания, приведены современные представления о биомаркерах биполярного расстройства. Описаны закономерности течения биполярного расстройства, включая гендерные особенности, продром и тримодальное распределение по возрасту начала. Дана характеристика структуры и динамики когнитивных нарушений у пациентов с биполярным расстройством. Представлены подходы к дифференциальной диагностике и терапии биполярного аффективного расстройства с акцентом на антипсихотики третьей генерации.
Ключевые слова
биполярное аффективное расстройство, коморбидность, биомаркеры, диагностика, терапия
Библиографические ссылки
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